It is the connectivity capability that makes them different from each other.
While the Epson L380 only supports USB connection, the Epson L385 supports both the wired and wireless connection.
They both also have integrated wireless connectivity.

Along with the connectivity option, the Epson L385 supports Epson Connect.
Cheaper to Run
The real strength of a tank-based printer is always its ink system.
It has a massive amount of ink that will save you from buying another set too soon.

Better yet, it can be refilled until the printer reaches the end of its lifetime.
This is something that Epson L385 Resetter can do.
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