So how do you tell which process has the file open, or which app is using it?
There are multiple ways of checking which process or app is using the file you want to modify.
It can also be used to manage the processes.

punch in in resmon and pressEnterto launch the Resource Monitor.
This can be achieved usingMicrosofts Handlecommand-line utility, but note that it will only inform you about the process.
You cannot kill the process using this tool.

you’ve got the option to however use theTask Manageror the kill command to end the process.
Now press theWindows Key + Rto initiate the Run Command box.
throw in in cmd and pressCTRL + Shift + Enterto run anelevated Command Prompt.

Now use the cd command to change the current directory to the extracted Handle folder.
You may now use this information to kill the process from the Task Manager, orusing the Command Prompt.
Many of these tools are freeware and safe to run on your Windows computers.

However, one cannot always restart a PC when coming across such issues.
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source: www.itechtics.com