PaintTool SAI is one of the widely used painting software.
If you also want to hide the menu bar, just press F11 once again.
Most operations in PaintTool SAI can be executed with keyboard shortcuts.

Creating a layer is also as simple as pressing a few keys on the keyboard.
With layers, you might make separate edits to the painting so that they will not affect each other.
PaintTool SAI comes with a number of brushes and users are allowed to add their own brushes.

In the tool panel there are empty slots which you might use to add new brushes.
It is also amazing that such a small size software offering a high amount of customizations.
Moreover, the communitys contributions make the software more capable than it already is.