This profile is remembered and automatically selected on subsequent boot-ups.
Here is more information onhow to bootfrom a USB drive if the subject is unfamiliar to you.
USB drives tested
None of these are officially “certified” for Windows To Go.

The ancient Patriot drive was included out of curiosity and its performance was as poor as you’d expect.
We purchased this drive at therecommendation of a reader.
For reference, the write speed on a conventional hard drive is around 70MB/s.
There may be more 32-bit systems in existence overall, but most of them are also outdated.
Fortunately, there are several ways to get an Enterprise image.
Install.wim and .esd are image files with system data that can be used for a Windows installation.
This is a hardware attribute of the drives.
Here’s a quick guide on the Windows To Go creation process from Rufus 3.3.1.
Do you still want to proceed?
However those tools are almost never provided to the public."
Install.wimandinstall.esdcontain compressed OS data that can be used to create a Windows installation or a To Go drive.
After that, the operating system loads up as if it were installed on any other drive.
If you’re going this route, here’s another detailedguideon configuring Windows 10 components.
Getting started in NTLite: Add a .wim or .esd file.
Right click that file when it appears in the software and choose “load.”
When the loading process completes, you should see options on the left column.